Anti-proliferative activities of 4H-pyran derivatives synthesized from benzoylacetone
نویسندگان
چکیده
ABSTRACT. Benzoylacetone (1) underwent a series of multi-component reactions with aromatic aldehydes and malononitrile or ethyl cyanoacetate to produce the pyran derivatives 4a-f. The latter compounds reacted yield condensation products 5a-m. On other hand, reaction 4a-f either diazonium salts 6a-c yielded arylhydrazone 7a-i. adehydes cyclohexan-1,3-dione produced 9a-c. Compound 1 Gewald’s elemental sulfur cyanacetate yielding thiophene 10a,b. Evaluations synthesized were carried out against some selected cancer cell lines most active further evaluated seventeen classified according disease. Morphological changes A549 line by effect compound 7k was studied using microenvironment lung tissue where an excellent results obtained.
 
 KEY WORDS: Benzoylacetone, Multi-component reactions, Pyran, Thiophene, Arylhydrazone, Cytotoxicity
 Bull. Chem. Soc. Ethiop. 2023, 37(2), 405-425. DOI: https://dx.doi.org/10.4314/bcse.v37i2.12
منابع مشابه
Synthesis and Antimicrobial Evaluation of 4H-Pyrans and Schiff Bases Fused 4H-Pyran Derivatives as Inhibitors of Mycobacterium Bovis (BCG)
The focus of our study is the synthesis and biological activity evaluation of a series of 4H-Pyran compounds and schiff bases fused 4H-Pyran derivatives which are known to possess a wide variety of biological activities. In this paper at first a simple and efficient one-pot synthesis of 4H-Pyran s from the three-component reaction between malononitrile, aldehydes, and active methylene compounds...
متن کاملSynthesis and Antimicrobial Evaluation of 4H-Pyrans and Schiff Bases Fused 4H-Pyran Derivatives as Inhibitors of Mycobacterium Bovis (BCG)
The focus of our study is the synthesis and biological activity evaluation of a series of 4H-Pyran compounds and schiff bases fused 4H-Pyran derivatives which are known to possess a wide variety of biological activities. In this paper at first a simple and efficient one-pot synthesis of 4H-Pyran s from the three-component reaction between malononitrile, aldehydes, and active methylene compounds...
متن کاملDesign, synthesis and in vivo anti-inflammatory activities of 2,4-diaryl-5-4H-imidazolone derivatives.
A series of 2,4-diaryl-5(4H)-imidazolones were prepared and evaluated for their anti-inflammatory activities. Some selected 2,4-diaryl-5(4H)-imidazolones exhibited excellent anti-inflammatory activity in the carrageenan-induced rat paw edema model. Structure Activity Relationships within the series were studied. The substitution at the N-sulfonamide moiety by a small hydrophilic acetyl group re...
متن کاملCe-ZSM-11 Zeolite: An Efficient Heterogeneous Catalyst for One-Pot Synthesis of 4H-Pyran Derivatives
ZSM-11 zeolite was synthesized by hydrothermal treatment and cerium ion was incorporated by the ion exchange method. The catalytic activity of cerium modified ZSM-11 zeolite was tested for the one-pot synthesis of 4H-pyran derivatives by cyclocondensation of aromatic aldehyde, malononitrile, and ethyl acetoacetate. The synthesized catalyst was characterized by Po...
متن کاملA clean and efficient synthesis of spiro[4H-pyran-oxindole] derivatives catalyzed by egg shell
Egg shell has been utilized as a natural, green, reusable and eco-friendly reagent for the synthesis of spiro[4H-pyran-oxindole] derivatives by one-pot multicomponent reaction of isatins, 1,3-diketones, and malononitrile/ ethyl cyanoacetate. Good functional group tolerance and broad scope of usable substrates are other prominent features of the present methodology.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of The Chemical Society of Ethiopia
سال: 2022
ISSN: ['1011-3924', '1726-801X']
DOI: https://doi.org/10.4314/bcse.v37i2.12